Lipopolysaccharides isolated from Eikenella corrodens but not from Porphyromonas gingivalis W83 induce proatherosclerotic inflammatory responses in human coronary artery endothelial cells
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Lipopolysaccharides isolated from Eikenella corrodens but not from Porphyromonas gingivalis W83 induce proatherosclerotic inflammatory responses in human coronary artery endothelial cells
Gualtero Escobar, Diego Fernando; Bernau Gutiérrez, Sebastián; Viafara, Sergio; Buitrago Ramírez, Diana Marcela; Fontanilla Duque, Martha Raquel; Lafaurie Villamil, Gloria Inés; Universidad Nacional de Colombia, UNAL; Universidad de Kentucky, UK; Universidad El Bosquegualterodiego@unbosque.edu.co
Eikenella corrodens and Porphyromonas gingivalis are oral microorganisms associated with the periodontal disease and have been identified in atherosclerotic lesions. The pro-atherosclerotic potential of a periodontopathic species depends on the ability of the strain to infect the endothelium. Lipopolysaccharide (LPS) from atherosclerosis-associated bacteria causes innate inflammatory responses in the pathogenic processes induced by microorganisms. The purpose of this study was to compare the pro-inflammatory responses of human coronary artery endothelial cells (HCAECs) to LPS isolated from E. corrodens 23834 and P. gingivalis W83.