Insuasty Insuasty, Henry Edgardo; Insuasty Obando, Braulio Argiro; Castro, Edison; Quiroga Pueyo, Jairo; Abonia González, Rodrigo; Nogueras, Manuel; Cobo, Justo (2012)
Abstract:Novel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines were synthesized from three different approaches. The first one, involved a one-step reaction between 5-amino-3-hetaryl-1H-pyrazoles and O,S-diethyl hetaroylimidothiocarbonates or S,S-diethyl hetaroylimidodithiocarbonates under solvent-free conditions employing microwave irradiation as the energy source. In the second approach, conventional heating under reflux in DMF as solvent was used instead of the microwave irradiation; and the third one was achieved from a two-step sequence through the treatment of 5-amino-3-hetaryl-1H-pyrazoles with hetaroyl isothiocyanates and the subsequent S-alkylation and cyclization process in DMF as solvent. Some intermediates were isolated and characterized to support the regiochemistry of the studied reactions. The structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.
Es proyecto?:no
Autor:Insuasty Insuasty, Henry Edgardo
Programa Nal. Colciencias:Programa de ciencias básicas
Insitución cofinanciadora:Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias
Institución participante:Universidad del Valle, Univalle
Tipo de producto resultado de investigación:info:eu-repo/semantics/article
Fecha:2012
Proyecto id:1104-489-25175
Nombre de proyecto principal:Síntesis de nuevas pirazolo[1,5-a]-1,3,5-triazinas sustituidas con fragmentos amino y anillos heterocíclicos de reconocida bioactividad, en condiciones libre de disolvente, empleando irradiación con microondas
Comunidad vinculada:Comunidad científica colombiana