Cambios genéticos temporales y microgeográficos de Aedes aegypti en Medellín, Colombia

Abstract

Introduction: Aedes aegypti populations may experience changes in abundance and genetic diversity in addition to changes in their evolutionary capability to respond to vector control. The knowledge on the changes in genetic variation on a spatial-temporal scale of the epidemiological understanding or dengue and supports the appropriate and timely design of vector control strategies. Objective: To assess the genetic changes, diversity and gene flow in six microgeographical populations of Ao. Aogypti in Medellin for different epidermiological periods of dengue. Materials and methods: A total of 255 specimens frörm six different neighborhoods in Medellin were used to assess variations in the CO1 mIDNA haplotype composition, diversity and genetic differentiation for an epidemic period (2010) and an endemic period (2012). Results: Two groups of highly differentiated haplotypes were present in both periods, and a high frequency was evaluated for all neighborhoods. The highest haplotype diversity was recorded in 2012, but the maximum nucleotide diversity was recorded in 2010. No significant correlation between genetic and geographic distances was observed. Conclusions: The genetic composition of Ao. aegypti varies over time without a predictable pattern In addition, the presence of a high-frequency haplotype in both periods could indicate a persistent ariatry adapted to vector control. However, the simultaneous movement of highly differentiated CO1